Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential.

The proportions of carriers and non-carriers of predicted pathogenic variants in the three population groups are highly significant different (p = 0.000009), due to the low proportion of carriers in Europeans (two by two population groups comparisons: Africans × Asians, p = 0.355; Africans × Europeans, p = 0.000013; Asians × Europeans, p = 0.00018).

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