The Cochrane meta-analysis showed a possible trend towards improved survival for patients treated with sirolimus compared with those receiving a calcineurin inhibitor. 17 This analysis, however, was underpowered as they had data on only 631 patients from six trials. 17 We investigated the effect of sirolimus on development of cancer and on survival among transplant recipients using data from randomized trials.
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Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data.
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