marginally significantp-value = 3.1×10 −2
Functional in silico analysis of 375 genes affected by protein-altering de novo variants (missense predicted as probably damaging by Polyphen, nonsense, conserved splice site (±2) and frameshift Indels) [20] , [21] , [22] , [23] and this study ( Table S5 ) revealed a marginally significant enrichment for genes involved in cellular component morphogenesis (GOTERM_BP_FAT Gene Ontology, Benjamini p-value = 3.1×10 −2 ) and genes expressed in brain tissues (TISSUE Expression, Benjamini p-value = 5.4×10 −8 ).