Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation.

18 However, this study was restricted by a small sample size (94 patients with pain and six healthy controls), wherein most cytokines failed to reach significance after adjusting for multiple testing. 18 Due to the important relationship between the presence of pain and illicit substance abuse, as well as the overwhelming presence of pain within the methadone setting, it is imperative that we target our efforts toward understanding the characteristics of this patient population.

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This model included multiple covariates identified as or trending toward significance during the univariate analysis (age, IFN-γ, and response to treatment [COA]).

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