Remarkably, a highly significant enrichment of known dysregulated miRNAs was observed: 164 miRNAs in the inferred GRN were previously shown to be dysregulated in tumors of the NCI-60 data set (odds ratio = 6.0, Fisher test P = 4.5 × 10 -12 ; Supplementary Table S3).
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Large-scale modeling of condition-specific gene regulatory networks by information integration and inference.
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