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HIV-1 infection causes a down-regulation of genes involved in ribosome biogenesis.

PLoS One · 2014 · PMC4252078 · PMID 25462981

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an overall trendno p-value reported
We found a marked global alteration of gene expression following infection, with an overall trend toward induction of genes, indicating widespread modification of the host biology.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.