HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.

PLoS One · 2014 · PMC4254744 · PMID 25469638

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marginal significancep = 0.06so close (0.05 < p ≤ 0.1)

Conversely, TLR4 expression decreased dose-dependently with significantly more TLR4 expression seen in 1 ng/ml (p = 0.004) and with marginal significance at 5 ng/ml HMGB1-stimulation (p = 0.06) ( Figure 2E ). 3.5 HMGB1 induces Pp38 MAPK pathway To better understand the MAPK pathway activation by HMGB1, a semi quantitative assessment of phosphorylated (P) MAPK proteins was carried out.

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