Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy.

At 3 dpf, there was a highly significant reduction in the birefringence of trg mutants to 45±2% of that of siblings, which persisted through to 6 dpf ( P <0.01, n =3) ( Fig. 1C ).

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