A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons.

To determine whether changes in WISH signal may be significant, we measured mean intensities of WISH signal within defined anatomical domains of marker gene expression in five or more images of control and experimental (mutant) embryos, and analyzed data for significant differences in mean intensities using the Mann-Whitney test (see Methods ; all measurements and statistical analyses are documented in Table S1 ).

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