Immunity, safety and protection of an Adenovirus 5 prime--Modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves.

A highly significant increase ( P < 0.001) in PPD-J specific FoxP3 expressing CD4 + (Figure 8 A), WC1 + (Figure 8 B) and CD8 + (Figure 8 C) T cells was observed in the Sham vaccinated group compared to the HAV vaccinated animals from week 24 onwards (Figure 8 ).

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