Physical exercise and weight loss for hip and knee osteoarthritis in very old patients: a systematic review of the literature.

These results are highly significant given that such trials are subject to strong methodological constraints: single-blind is sometimes difficult to enforce [ 8 ], and low sample sizes frequently limit statistical power, which in additioncould also be reduced by the possible effect of sham treatment in the control group: brochures and educational sessions may encourage controls to increase their activity by themselves, and trips to the centre can provide general stimulation [ 13 ].

also in 132,142 other papers