Spatio-temporal distribution of malaria and its association with climatic factors and vector-control interventions in two high-risk districts of Nepal.

Conclusions Despite a significant decline in malaria cases at the national level, an increasing trend of malaria incidence in Kailali district, with persistence of malaria cases in the same villages where vector control interventions had been in place, a shift of malaria hotspots to new villages in Morang district without vector control interventions, and a positive association of malaria incidence with temperature indicates worries about the elimination of malaria from the country.

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