A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression.

Oncotarget · 2014 · PMC4259441 · PMID 25226613

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highly significantno p-value reported

Moreover, Figure 3D shows that TIMP3 -silencing in MPT0G013-treated HUVECs led to a highly significant increase in the expression of phosphorylated Akt and ERK relative to that in the siCTL control group.

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