Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences.

Mutational profiles and survival Tumors harboring cell cycle alterations were associated with better overall survival (mean survival cell cycle wt: 50.7 months versus cell cycle mutant: not reached) but with no differences in disease free survival (Figure 5 ), however, the association was only of borderline significance (p=0.053).

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