The basis for this laterality has not been addressed at the cellular or molecular level, an oversight that may be significant because patient survival is reported to differ according to primary tumor situs ( 1 – 2 ).
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Mammary glands exhibit molecular laterality and undergo left-right asymmetric ductal epithelial growth in MMTV-cNeu mice.
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Whereas the relationship between L-R gene expression and outcome fell just short of significance in the HER2 over-expressing subset ( Fig. 4B ), the relationship was significant in the HER2− subset ( Fig. 4C ).