Most notably, highly significant DMPs were identified in the PFC (Table 1 ), with probes in four genes being significantly associated with schizophrenia at a false discovery rate (FDR) ≤0.05: GSDMD (cg26173173: control = 78.9 ± 3.0, schizophrenia = 83.3 ± 1.3, FDR = 0.03); RASA3 (cg24803255: control = 65.1 ± 4.7, schizophrenia = 56.4 ± 4.1, FDR = 0.03); HTR5A (cg00903099: control = 11.5 ± 1.7, schizophrenia = 9.2 ± 1.2, FDR = 0.03); and PPFIA1 (cg08171022: control = 53.1 ± 3.2, schizophrenia = 47.6 ± 3.2, FDR = 0.03) (Figure 1 A).
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Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
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