A worrying trend is the increased prevalence of non-nucleoside RT inhibitor (NNRTI) related mutations in newly diagnosed patients [ 3 , 5 ], as single NNRTI mutations, such as the frequently observed K103N mutation, can result in high levels of resistance against first generation NNRTIs [ 6 ].
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Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.
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