Effect of adrenergic blockers, carvedilol, prazosin, metoprolol and combination of prazosin and metoprolol on paracetamol-induced hepatotoxicity in rabbits.

These findings are in agreement with the results of Randle et al .[ 2 ] The mechanism behind the hepatoprotection of prazosin is not well defined, however, marked reduction in MDA levels both in serum and in liver homogenate, with highly significant increase in serum GSH may suggest antioxidant mechanism as an important factor, and a hepatoprotection mechanism related to α 1 -Adrenoceptor antagonism remains to be clarified. α 1 -adrenoceptor blockers completely prevent erythrocytes accumulation within hepatic sinusoids and reduce hepatic perfusion caused by elevated circulating catecholamine associated with paracetamol toxicity.

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