POT1 loss-of-function variants predispose to familial melanoma.

Nat Genet · 2014 · PMC4266105 · PMID 24686849

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

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highly significantP = 1.54×10 −5actually significant

Analysis of nucleotides coding for these 24 OB domain residues identified one non-synonymous change in 6,498 control exomes 14 compared with three in 105 melanoma families, emphasizing a highly significant enrichment of variants in the melanoma cohort ( P = 1.54×10 −5 ) ( Online Methods , Supplementary Tables 6 - 7 ).

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