A study from France found that 32.5% of girls with appearance of public hair between the ages of 4 and 8 had BMI of >2SD and that the correlation between BMI Z score and serum DHEA-S was highly significant.[ 58 ] Rodent and human studies propose that leptin may be the critical link between body fat (obesity) and earlier puberty.[ 59 60 ] Leptin deficiency leads to failure of puberty in mice and humans that can be treated by leptin administration.
1
—
—