Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.

Nat Genet · 2014 · PMC4267534 · PMID 24487275

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Genome wide expression analysis of HSC-enriched cells from control and Lis1 null mice revealed a highly significant loss of core genes that form the stem cell signature 16 – 18 ( Supplementary Fig. 6 ), as well as changes in genes such as Pim1 and Socs3 that play important regulatory roles in hematopoietic stem/progenitor cell maintenance and differentiation ( Fig. 2e ).

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