By restraining maximal and minimal motif size to 20 bases and four bases, respectively, we identified four highly significant motifs: 5′-TCTAGA-3′, 5-TGA(N) 7 TATC-3, 5-AAG(N) 8 TTTG-3 and 5-AAG(N) 8 TTCG-3 (N represents any of the four nucleotides) (Figure 3A ).
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qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data.
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