The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition.

Nucleic Acids Res · 2014 · PMC4267635 · PMID 25414359

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barely significantno p-value reported

We have previously shown that the promoter of the Wnt target gene SP5 is strongly regulated by the C-clamp in a Helper site-dependent manner and therefore as expected, dnTCF1EWT showed strong binding to the SP5 promoter, whereas dnTCF1Emut showed weak, barely significant binding to the promoter (Figure 2D ) ( 15 ).

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