miRNAs can be generally associated with human pathologies as exemplified for miR-144.

BMC Med · 2014 · PMC4268797 · PMID 25465851

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highly significantno p-value reported

The validation in center 1 reached a highly significant P value of 3.66 × 10 −6 , showing a significant downregulation of this miRNA in diseases (on average 2.8-fold).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.