A genetic variant in 12q13, a possible risk factor for bipolar disorder, is associated with depressive state, accounting for stressful life events.

Initial logistic regression analysis (independent variables: age, sex, SLE, and neuroticism) revealed that neuroticism showed a highly significant association with the depressive state ( S2 Table ).

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Logistic regression analysis revealed a marginally significant interaction (genetic variant × SLE) at rs4523957 (P uncorrected = 0.0034) with depression and a significant association of single nucleotide polymorphism identified from evidence of BD GWAS (rs7296288, downstream of DHH at 12q13.1) with depression as the main effect (P uncorrected = 9.4×10 −4 , P corrected = 0.0424).

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