53 It is therefore highly significant that, under the fermentation conditions tested, LtmK catalyzes the desaturation of 14 to 1 with minimal formation of the hydroxylated products, 13 and 15 (Figure 3 B).
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Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
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