Dexpramipexole is ineffective in two models of ALS related neurodegeneration.

PLoS One · 2014 · PMC4272269 · PMID 25526593

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marginally significantno p-value reported

In primary cortical neurons transfected with either mutant or wild-type human TDP43, a marginally significant improvement in a single indicator of neuronal survival was observed, and only at the 10 μM RPPX treatment.

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