Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia.

Interestingly, when the CD11b + CD45 dim microglial population was evaluated in mice treated with either XPro1595 or etanercept and allowed to survive for 24-hours, the estimated number of CD11b + CD45 dim microglia in the lesioned cortex had increased in etanercept-treated mice, though not quite significant, and significantly in XPro1595-treated mice as compared to saline-treated mice (Figure 3 B, upper left graph).

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