highly significantP < 0.0001
When we focused on the distribution of genotypes containing the mutant alleles (DG+GG and RH+HH), we found highly significant differences between cases and controls ( χ 2 = 16.2, P < 0.0001 for TAP1 -rs1135216 and χ 2 = 4.5, P = 0.03 for PSMB9 -rs17587). 3.3.