The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage.

BMC Biol · 2014 · PMC4275981 · PMID 25471935

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highly significantP = 8.7E-6actually significant

However, when the same test was performed on data from Pfh1-depleted cells, there was a highly significant association between high Cdc20 occupancy at G4 motifs and nearby damage ( P = 8.7E-6; Table 4 ).

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