A Fractional Factorial Design to Study the Effect of Process Variables on the Preparation of Hyaluronidase Loaded PLGA Nanoparticles.

Effect on Zeta Potential Although individual variables as such did not have significant effect on zeta potential ( Table 1 ), the effect of homogenization speed on zeta potential became highly significant ( P value: 0.02), in the presence of interaction between PVA concentration and homogenization time ( P value of combined effect of PVA concentration and homogenization time was 0.04) ( Table 2 and Figures 3 and 4 ). 3.3.

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