Using an innovative multiple regression procedure in a cancer population (Part II): fever, depressive affect, and mobility problems clarify an influential symptom pair (pain-fatigue/weakness) and cluster (pain-fatigue/weakness-sleep problems).

However, pain × fever, pain × fever × sleep, and pain × fever × fatigue/weakness, significant at P <0.05 or P <0.01 in separate three-way (second-order) explanatory models (regressions 2 and 3), all become highly significant ( P <0.001) in this simultaneous model (regression 4).

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