Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?

Influence of HIV status on plasma levels of sCD14, sCD163 and CXCL10 Comparing normalised (log-transformed) levels of plasma biomarkers in the HIV-infected and healthy control groups (ANOVA with Bonferroni correction as appropriate for multiple comparisons), we found a highly significant difference in plasma sCD14 levels in the HIV + group compared to controls ( Fig. 4A ; p<0.001), with no detectable influence of HIV suppression on sCD14 levels compared with the viremic HIV group (p>0.9).

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