Quantifications of Lef1 binding to the conserved binding sites revealed that Lef1 binding to CNE195 and CNE190, but not CNE114 was highly significant and specific to the analyzed CNE regions ( Fig. 3E ).
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Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo.
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