TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.

However, a trend towards significance was observed when the two cohorts were combined ( β =0.111±0.059, 95%CI −0.0041 to 0.2268; P =0.053), suggesting that an underlying effect on degree of steatosis may be present but of relatively small size.

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This highly significant effect was consistently demonstrated across all the cohorts studied and was independent of potentially confounding factors including gender, age at time of biopsy, BMI, T2DM and PNPLA3 rs738409 genotype.

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