Developmental regulation of human cortex transcription and its clinical relevance at single base resolution.

Nat Neurosci · 2015 · PMC4281298 · PMID 25501035

Europe PMC DOI

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The sentences

highly significantp < 10 −100actually significant

There was highly significant overlap (at empirical p < 10 −100 , see Methods for permutation procedure) between the DERs and histone marks associated with active chromatin, including H3K36me3 (OR=13.32), H3K4me1 (OR= 3.00), H3K4me3 (OR=5.66), and H3K9ac (OR=4.82).

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marginally significantp < 0.05actually significant

We retained DERs that were at least marginally significant (p < 0.05) in this replication dataset, yielding 50,560 (80.1%) genome-wide significant DERs that were also differentially expressed in this independent DLPFC dataset, which were used for the analyses described below.

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