TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.

EMBO J · 2014 · PMC4282642 · PMID 25391662

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closest p · 0.0× alpha

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highly significantP = 5.3 × 10 −181actually significant

While about 8% of the worm genome is arranged antisense to another gene (Thierry-Mieg & Thierry-Mieg, 2006 ), approximately 35% of increased and decreased transcripts were arranged in this manner, representing a highly significant enrichment ( P = 5.3 × 10 −181 , hypergeometric distribution (hgd)) (Fig 1 B).

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