Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population.

The minor A allele of rs2228611 was associated with a lower risk of CAD ( p = 0.034); modest effect in the additive analysis but also marginal significance was found in the recessive model [OR additive = 0.404 (0.184, 0.884), p = 0.023 and OR recessive = 0.452 (0.213, 0.963), p = 0.040] after adjusting for confounders.

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While the rs2336691 A allele were associated with a higher risk of developing CAD ( p = 0.037); borderline significant association in both additive and dominant models [OR additive = 1.632 (1.030, 2.583), p = 0.037 and OR dominant = 1.599 (1.020, 2.507), p = 0.040].

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