Barely Significant
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Pharmacokinetic overview of ethinyl estradiol dose and bioavailability using two transdermal contraceptive systems and a standard combined oral contraceptive.

Int J Clin Pharmacol Ther · 2014 · PMC4285808 · PMID 25295716

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borderline significantno p-value reported
In addition, there was negligible influence from demographic covariates, and although body weight had a small but borderline significant effect on EE clearance, this was considered unlikely to be clinically meaningful.

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