Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

Oncogene · 2014 · PMC4287650 · PMID 24858037

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may be significantno p-value reported

Therefore, the higher activity of iPLA2 by PS2 knockout may be significant in the regulation of genes involved in cell proliferation, metastasis and angiogenesis, leading to an increase in lung tumor development in PS2 knockout mice.

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