Glucagon-like peptide 1 and dysglycemia: Conflict in incretin science.

Indian J Endocrinol Metab · 2015 · PMC4287769 · PMID 25593851

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Although, fasting GLP-1 were normal in all groups including type 2 diabetes.[ 7 ] This study suggested a highly significant (53%) reduction in incremental GLP-1 concentrations and overall (19%) reduction in the AUC in type 2 diabetes compared to healthy controls.[ 7 ] Subsequently, several other investigators also supported this finding and suggested a progressive decrease in GLP-1 level and GLP-1 responsiveness with th

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