Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

EMBO Mol Med · 2014 · PMC4287973 · PMID 25253726

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highly significantno p-value reported

Gene set enrichment analysis (GSEA) showed that multiple sets of MYC-activated genes were downregulated upon depletion of HUWE1, and this was statistically highly significant (Fig 2 D, upper panel) (Subramanian et al , 2005 ).

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