Characterization of age signatures of DNA methylation in normal and cancer tissues from multiple studies.

The correlation between the actual ages of the combined normal samples and their predicted ages using the model was highly significant (R = 0.91, P = 0.002 from 10,000 random selection tests using all loci in the platform; Figure 5 A), which indicates that the DNAm levels of the age-associated signature sites can be used to predict the age of tissues, regardless of tissue type.

also in 132,142 other papers