Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice.

Only one QTL (affecting B81, IghV1-75) showed a marginally significant interaction with sex, and none significantly interacted with diet, which was expected given the lack of dietary effects on the individual IghV abundance.

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Remarkably, 36 of the 56 QTLs had LOD scores >10, with 34 of these highly significant QTLs localized to a segment on Chr 12 that encompasses the IgH region.

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