Behavioral architecture of opioid reward and aversion in C57BL/6 substrains.

For D8-D1 freezing bouts, the Treatment x Strain interaction was not significant [ F (1, 180) = 2.2; p = 0.14]; however, NAL-trained J mice clearly demonstrated a highly significant increase in the number of freezing bouts relative to SAL-trained J mice [ t (98) = 5.8; p = 1.1 × 10 −7 ] and relative to NAL-trained NJ mice [ t (85) = 4.2; p = 7.0 × 10 −5 ].

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