Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area.

Cumulative frequency plots (Figure 1 B) show a highly significant increase in inter-event interval (i.e. a decrease in event frequency) induced by DAMGO (KS test P < 0.001 vs. baseline) that persisted after 10-min incubation and was reversed by the opioid agonist naloxone.

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