National record linkage study of mortality for a large cohort of opioid users ascertained by drug treatment or criminal justice sources in England, 2005-2009.

Drug Alcohol Depend · 2015 · PMC4294586 · PMID 25454405

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highly significantno p-value reported

Our analysis provides the first demonstration of a highly significant, age-related increase in opioid users’ drug-related poisoning mortality rate that persists beyond 45 years of age.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.