The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.

Redox Biol · 2014 · PMC4297928 · PMID 25462066

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highly significantno p-value reported

An upregulation of COX2 has been shown in familial adenomatous polyposis (FAP) and in the Apc Min mouse model which resembles FAP and this was associated with a highly significant increase in various etheno-DNA lesions [13–16] .

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