The rs340874 PROX1 type 2 diabetes mellitus risk variant is associated with visceral fat accumulation and alterations in postprandial glucose and lipid metabolism.

Genes Nutr · 2015 · PMC4298567 · PMID 25601634

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highly significantno p-value reported

Similarly, no association of the rs340874 SNP with fasting or 2 h OGTT insulin was found in the large meta-analysis comprising more than 120 K individuals, while there was a highly significant effect of the studied PROX1 variant on fasting glucose and type 2 diabetes mellitus risk (Dupuis et al. 2010 ).

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