marginally significantP = 0.0445
Furthermore, in each successive decade, the median time from initial presentation of symptoms to death remained significantly prolonged in skin versus nonskin IVL in 1960-1980s ( P = 0.0001), 1990s ( P = 0.0211), and 2000s ( P = 0.0007), while the median time from diagnosis to death was marginally significant in 1960–1980s ( P = 0.0445) but insignificant in the 1990s ( P = 0.3287) and 2000s ( P = 0.2946).